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Ulcerative Colitis

Discover the SUNSCAPE Studies, a study program for people affected by moderate to severe UC

The SUNSCAPE Studies are clinical trials evaluating the effectiveness and safety of an investigational drug to see if it can treat moderately to severely active ulcerative colitis (UC).

The studies include several parts. In SUNSCAPE-1, you may receive the investigational study drug or a placebo for 12 to 24 weeks. Depending on your response, you may qualify to move on to SUNSCAPE-2, a maintenance part for 40 weeks. At the end, everyone may join the open-labeled extension part and continue receiving the investigational study drug.

You may be eligible for the SUNSCAPE Studies if you:

• Are 18 years or older (or at least 16 in some countries).

• Have been diagnosed with moderate to severe UC at least 3 months ago that is currently active.

• Have frequent bowel movements with visible bleeding.

• Have not responded well to previous UC treatments or could not tolerate them.

• Are willing to follow all study procedures: site visits, colonoscopies, and symptom tracking.

GOOD TO KNOW

Clinical trials are always voluntary and free of charge. You may withdraw at any time. Additional eligibility requirements apply. If you have questions or need more information, speak to your study doctor.

Terms and Conditions

What Is Ulcerative Colitis?

Ulcerative colitis is a chronic inflammatory disease that affects the large intestine, also known as the colon. It belongs to a group of conditions called inflammatory bowel diseases (IBD). This condition causes inflammation and small ulcers to form in the inner lining of the colon, which can lead to ongoing discomfort and impact a person’s quality of life.

Ulcerative colitis is not contagious and is not caused by anything a person did wrong. Its exact cause is not fully understood, but it is believed to involve an abnormal response of the immune system, along with genetic and environmental factors. In simple terms, the body’s immune system mistakenly attacks healthy tissue in the colon.

How Does Ulcerative Colitis Affect the Body?

Inflammation usually begins in the rectum and may spread to other parts of the colon. Unlike some other digestive conditions, ulcerative colitis affects the colon in a continuous pattern, without healthy areas between inflamed sections. Symptoms can range from mild to severe, and each person’s experience may be different.

Common symptoms include frequent diarrhea, abdominal pain, rectal bleeding, an urgent need to have a bowel movement, fatigue, and weight loss. Many people experience flare-ups, when symptoms worsen, followed by periods of remission, when symptoms improve or temporarily disappear.

Impact on Daily Life

Living with ulcerative colitis can affect more than just digestion. Symptoms may interfere with work, school, social activities, and emotional well-being. Managing a long-term condition can be challenging, which is why medical guidance, clear information, and emotional support are essential.

Treatment and Ongoing Care

Although there is currently no cure for ulcerative colitis, treatments are available to help control inflammation, reduce symptoms, and improve quality of life. These may include medications, lifestyle adjustments, and regular medical monitoring. Clinical research also plays an important role in developing new treatment options for people living with this condition.

An Important Message

Ulcerative colitis is a lifelong condition, but with proper care and support, many individuals are able to live active and fulfilling lives. Learning about the disease is an important step toward understanding it and managing it with confidence.